Genitourinary Cancers | Matthew R Smith, MD, PhD

Consensus or Controversy? Clinical Investigators Provide Perspectives on the Current and Future Management of Prostate Cancer — Part 2: Our one-on-one interview with Dr Smith featuring emerging research and cases from his practice. Recent advances in the treatment of nonmetastatic CRPC (00:00) Effect of PSA doubling time on prognosis for patients with nonmetastatic disease (3:01) PSA doubling time and clinical decision-making for patients with M0 disease (7:59) Counseling patients with nonmetastatic disease about goals of therapy and expected side effects (10:26) Similarities and differences in the design, entry criteria and efficacy endpoints among the ARAMIS, SPARTAN and PROSPER trials (13:25) Comparison of the side-effect profiles of apalutamide, enzalutamide and darolutamide (15:35) Counseling patients receiving long-term ADT about treatment-related fatigue (18:35) Comparison of primary (metastasis-free survival) and secondary outcomes among the ARAMIS, SPARTAN and PROSPER trials (20:32) Choosing among darolutamide, apalutamide and enzalutamide (22:45) SPARTAN trial: PFS2 improvement with apalutamide for high-risk nonmetastatic CRPC (24:42) Outcomes, tolerability and appropriate use of abiraterone in combination with prednisone (26:27) Similarities and differences in the design, entry criteria and efficacy endpoints between the LATITUDE (ADT with abiraterone/prednisone or placebo) and ARCHES (ADT with enzalutamide or placebo) trials for patients with metastatic HSPC (29:46) Key clinical and practical factors guiding the selection of docetaxel versus abiraterone/prednisone for metastatic HSPC (35:39) Perspective on the intensification of therapy for patients with metastatic HSPC and suboptimal responses to ADT (39:08) Spectrum and frequency of somatic and germline DNA repair gene mutations in prostate cancer; activity of PARP inhibitors in patients with metastatic CRPC (40:57) Incidence of MSI-H/dMMR molecular phenotype in patients with prostate cancer; indications for testing and current role of immune checkpoint inhibitors (46:37) Results of a Phase II prospective trial of lutetium-177-PSMA-617 theranostics in metastatic CRPC (50:42) Novel immune checkpoint inhibitor-based combinations for metastatic CRPC (56:08)   Select publications