SCCAN Study: Extent of Radical Hysterectomy in Cervical Cancer with Nicolò Bizzarri

In this episode of the IJGC podcast, Editor-in-Chief Dr. Pedro Ramirez is joined by Dr. Nicolò Bizzarri to discuss the SCCAN study. Dr. Bizzarri is a former IJGC Editorial Fellow under the mentorship of Prof. Pedro Ramirez. He is a Gynecologic Oncologist at Policlinico Agostino Gemelli in Rome, president of the European Network of Young Gynecologic Oncologists (ENYGO), and he happily serves on the IJGC Editorial Board.   Highlights: International guidelines recommend tailoring the radicality of hysterectomy according to the known pre-operative tumor characteristics in patients with early-stage cervical cancer. However, the survival benefit associated with the extent of radical hysterectomy is still a matter of debate. Non-nerve-sparing radical hysterectomy was associated with improved 5-year disease-free survival compared to nerve sparing radical hysterectomy and represented an independent protective factor for risk of recurrence. Non-nerve sparing radical hysterectomy was associated with better 5-year disease-free survival in patients with tumors between 21-40 mm. In patients with early-stage cervical cancer, the extent of radical hysterectomy was associated with disease-free survival improvement in patients with tumors between 21-40 mm but not in patients with tumors ≤20 mm.